Scientific Research

Scientist No. of patients Design Main finding Link
Dr Emeir McSorley (Nee Duffy) 52 Patients were randomly assigned to one of four treatment groups (for 24 weeks);
1) 3g fish oil and 3 mg copper
2) 3g fish oil
3) 3mg copper
4) placebo
Patients in the groups receiving fish oil had a reduction in disease activity, as measured by SLAM-R. Copper had no effect on disease activity.
 

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Dr Stephen Wright 60 Patients were randomly assigned to one of 2 treatment groups (for 24 weeks):
1) 3 g fish oil
2) Placebo
Patients consuming 3g fish oil daily had an improvement in health, as measured by SLAM-R and BILAG. They also had a reduction in inflammation, as measured in the blood ( using 8-isoprostanes as a marker).
 

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Dr Ian Gourley 95 Patients donated a blood sample and had their medical history examined. Patients who tested positive for Anticardiolipin antibodies (ACA) in their blood where more likely to have a history of venous thrombosis. ACA is an immune complex that targets the inner part of a cell.
 

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Dr Elisabeth Ball 50 Lupus,   40 Rheumatoid Arthritis  Patients had ultrasound scans of their hands and blood measures of immune markers taken. Patients with higher “IL-6” in their blood were more likely to suffer from arthritis. IL-6 is an immune marker that promotes inflammation within the body.
 

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Dr Leanne Doherty (Nee Breslin) 52 (winter), 50 (summer) 52 SLE patients were recruited onto an observational study during the winter (November-March) and followed up during the summer months (June-July) (n=50). Vitamin D status was measured in the blood and measures of health were taken. There was a relationship between disease activity (BILAG) and vitamin D status – whereby those with a higher status had a lower disease activity score. Ninety eight percent of patients had inadequate vitamin D status. Patients suffering from fatigue had the lowest vitamin D status.
 

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Thesis available at the University of Ulster Coleraine library
Dr David Armstrong 8 Lupus, 3 Rheumatoid Arthritis, 3 Healthy The patient provided a blood sample which was analysed for immune complexes that target DNA. These complexes were isolated and incubated The increased cell turnover in Lupus was attributed to an immune complex that targets DNA (ds-DNA autoantibody).
 

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Dr Sahena Haque 53 (with coronary heart disease, (without coronary heart disease) Patients were recruited from multiple centres in the UK and Ireland. A medical history was assessed to establish coronary heart disease and medical treatment. Male Lupus patients are at an increased risk of coronary heart disease compared with females. Patients suffering from CHD were more likely to have been treated with corticosteroids and azathioprine.
 

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Dr Michelle McHenry 141 Lupus, 138 Healthy Participants provided a cervical smear which was tested for the presence of a marker of cervical cancer - human papilloma virus (HPV). SLE patients that tested positive for HPV were on average 13 years older than healthy participants that tested positive. The strain of virus was the same as that found in healthy participants.
 

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